Course Overview
The course aims to provide an introduction to the field of bioinformatics, with a focus on important bioinformatics tools, and resources. The course aims to use a combination of theoretical and practical sessions in order for participants to gain practical experience in using various tools and resources.
Intended Audience
The course is aimed at individuals from a molecular biology background who have a basic understanding of biochemistry and/or genetics and would like to become bioinformatics users. For an explanation on who 'bioinformatics users' might be, see Figure 2 in http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003496. A baseline level of the understanding of the central dogma of biology (DNA -> RNA -> Protein) is a requirement.
Keywords: Genetics, Genomics, Nucleic acids analysis
Skill level of training: Beginner
Language: English
Credential awarded: Letter of completion/attendance
Type of training: Blended/hybrid learning
Venue of the course: Local classrooms ( usually ~50 physical/online sites across Africa). Please be aware that the course is likely to make use of a combination of both physical and online sites depending on ongoing Covid-19 restrictions
Dates for the course: 18 April - 1 August 2023 every Tuesday and Thursday from 10:30 CAT to 14:30 CAT
Course organisers: Sindiswa Lukhele, Verena Ras, Tshinakaho Malesa, Shaun Aron, Sumir Panji and Nicola Mulder
Participation: The course is available to any classroom who meets the requirements and to any participant who is able to attend a physical/online classroom, provided they have been selected via the selection process. Should a classroom decide to host a face-to-face classroom, the participant must be able to attend this classroom in person for the duration of the course.
Course Sponsors: H3ABioNet, Local Classrooms
Course objectives

After this workshop participants should be able to:

  • Explain the use of bioinformatics
  • Name the key bioinformatics techniques and tools
  • Locate important biological databases and retrieve data
  • Use selected tools effectively to run specific bioinformatics analyses
  • Understand the strengths and limitations of the various techniques

 

 

Classroom applications

Registration for classrooms opens: Fri, 17/02/2023
Registration for classrooms closes: Sun, 12/03/2023
Link to classroom application form: <a href="https://redcap.h3abionet.org/redcap/surveys/?s=DRNEA4XW33A848DP"; rel="nofollow noopener noreferrer" target="_blank">https://redcap.h3abionet.org/redcap/surveys/?s=DRNEA4XW33A848DP</a>;
Notification date for successful classrooms: Fri, 17/03/2023
Maximum number of participants that may be accepted per classroom will be capped at 40

Participant applications

Registration for participants opens: Tue, 21/03/2023
Registration for participants closes: Thu, 06/04/2023

Syllabus and Tools

The course curriculum will cover the following main themes (subject to slight changes):

  • Bioinformatics resources and databases
    • Introduction to bioinformatics, biological databases and resources (NCBI and EBI), data formats, ontologies
  • Linux
    • Introduction to Linux, general overview of Linux environment, overview of command line interface, navigating Linux directory structure, manipulating files and directories, basic Linux commands
  • Sequence alignment theory and applications
    • Introduction to searching and sequence alignment, BLAST, pairwise sequence alignment
  • Multiple sequence alignment (MSA)
    • MSA theory, generating and interpreting MSAs using various tools, visualising and assessing MSA quality
  • Genomics
    • Overview of sequencing and annotation, Ensembl genome browser, Genetic variation, HapMap, 1000 genomes
  • Molecular evolution and phylogenetics
    • Molecular evolution, phylogenetic approaches and methods (Introduction and overview of methods)

 **All modules make use of predominantly web-based tools such as NCBI, Ensembl, etc.

Prerequisites: A basic background/understanding of biochemistry and/or genetics.

Prerequisites
Course limitations
This workshop will only provide a foundation for continued learning in bioinformatics and will not teach any advanced coding.
For more information, please visit https://www.h3abionet.org/training/ibt
Training material availability
<p>Training materials for this course are available here: <a href="https://zivahub.uct.ac.za/projects/Introduction_to_Bioinformatics_Training_Course_Materials/131552">https://zivahub.uct.ac.za/projects/Introduction_to_Bioinformatics_Training_Course_Materials/131552</a>;. Should you re-use any of these materials, please ensure that both the author/s of the material AND H3ABioNet are clearly credited.</p> <p><strong>Materials have been made available as a single archive per module containing lecture slides, transcribed videos, practical assignments and any other resources important to complete each module:</strong></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_1_Databases_and_Resources_Training_Material_Archive/19106741"; target="_blank" rel="noopener noreferrer">Module 1: Databases and Resources</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_2_Linux_Training_Material_Archive/19106744"; target="_blank" rel="noopener noreferrer">Module 2: Linux</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_3_Sequence_alignment_Training_Material_Archive/19106750"; target="_blank" rel="noopener noreferrer">Module 3: Sequence Alignment</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_4_Multiple_Sequence_Alignment/19106759"; target="_blank" rel="noopener noreferrer">Module 4: Multiple Sequence Alignment</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_5_Genomics/19106762">Module 5: Genomics</a></p> <p><a href="ttps://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_6_Phylogenetics/19106765" target="_blank" rel="noopener noreferrer">Module 6: Phylogenetics (2018 - 2021)</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_Module_6_2016_Structural_Biology/19129892"; target="_blank" rel="noopener noreferrer">Module 6: Structural Biology (2016 only)</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/IBT_-_Introduction_Week_Training_Material_Archive/19106738"; target="_blank" rel="noopener noreferrer">Introduction Week</a></p> <p><a href="https://zivahub.uct.ac.za/articles/educational_resource/Wrap_up_Week/19106768"; target="_blank" rel="noopener noreferrer">Wrap Up week</a></p> <p> <img 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" 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